Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase01:27

Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circadian amplitude and CLOCK 3111 polymorphism predict morning leptin in Arctic residents, independent of photoperiod.

Chronobiology international·2026
Same author

CLOCK genotype modulates associations between blue light exposure and circadian activity amplitude.

Physiology & behavior·2026
Same author

Population-Specific Circadian Drivers and MTNR1B Predict Arctic Morning Cortisol.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Circadian Light Hygiene Is Associated with Anemia Markers in Young Adults.

Biology·2025
Same author

Circadian Activity and Sleep Associated With Blood Lipids in Arctic Residents.

Journal of sleep research·2025
Same author

Higher morning NR1D1 (REV-ERBΑα) expression, robust circadian activity, and less light at night predict lower depression scores in arctic residents.

Journal of affective disorders·2025
See all related articles

Related Experiment Video

Updated: May 30, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Timing Nutriceuticals?

Franz Halberg1, Germaine Cornélissen, R B Singh

  • 1Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN 55455, USA.

The Open Nutraceuticals Journal
|August 5, 2011
PubMed
Summary
This summary is machine-generated.

Investigating the timing of nutriceuticals is crucial, as demonstrated by time-dependent effects of drugs and nutrition. Coordinated N-of-1 studies offer a robust method for examining these effects.

More Related Videos

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
08:54

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements

Published on: May 1, 2017

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction
11:07

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

Related Experiment Videos

Last Updated: May 30, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
08:54

NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements

Published on: May 1, 2017

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction
11:07

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

Area of Science:

  • Chronopharmacology and chrononutrition
  • Nutritional science and personalized medicine

Background:

  • The efficacy of drugs and nutritional interventions can vary significantly based on administration timing.
  • Understanding these time-dependent effects is essential for optimizing therapeutic outcomes.

Purpose of the Study:

  • To review existing evidence on time-dependent effects in pharmacology and nutrition.
  • To advocate for research into the optimal timing of nutriceutical interventions.
  • To highlight the value of N-of-1 studies for personalized timing investigations.

Main Methods:

  • Review of scientific literature on time-dependent drug and nutrient effects.
  • Emphasis on the statistical examination of individual patient data.
  • Advocacy for coordinated sets of N-of-1 studies.

Main Results:

  • Evidence supports significant time-dependent effects for both drugs and nutritional components.
  • N-of-1 studies, when aggregated and analyzed, provide powerful insights into individual variability.
  • Coordinated N-of-1 study designs are proposed as a superior method for inferential analysis.

Conclusions:

  • The timing of nutriceutical intake is a critical, under-investigated factor in efficacy.
  • Individually tailored, statistically robust N-of-1 studies are recommended for future research.
  • Integrating chronobiology principles into nutritional strategies can enhance health outcomes.