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Related Experiment Videos

Selective D1 and D2 dopamine antagonists decrease response rates of food-maintained behavior and reduce the

W A Corrigall1, K M Coen

  • 1Addiction Research Foundation, Toronto, Ontario.

Pharmacology, Biochemistry, and Behavior
|February 1, 1990
PubMed
Summary

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Heroin

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Heroin's discriminative stimulus is key to understanding opioid addiction.
  • Dopamine pathways are implicated in drug reward and reinforcement.

Purpose of the Study:

  • To investigate the neurochemical mechanisms underlying heroin's discriminative stimulus.
  • To determine the role of dopamine receptors in mediating heroin's effects.

Main Methods:

  • Animals were trained to discriminate heroin from saline using a two-lever, food-reinforced paradigm.
  • Dopamine antagonists (SCH23390 and spiperone) were administered to assess their effects on heroin discrimination.
  • Heroin's interaction with dopamine antagonists was examined.

Main Results:

Related Experiment Videos

  • The heroin stimulus was mediated by its metabolite, monoacetylmorphine.
  • Dopamine antagonists partially blocked heroin's discriminative effects at higher doses.
  • Dopamine antagonists affected food-maintained responding, indicating a role for dopamine in reward pathways.

Conclusions:

  • Dopamine appears to play a role in mediating the discriminative stimulus of heroin.
  • Opioids may influence dopamine release, contributing to their reinforcing properties.