Related Experiment Video
Updated: May 30, 2026

Systematic Bronchoscopy: the Four Landmarks Approach
Published on: June 23, 2023
Use of flexible bronchoscopy in pediatric patients receiving extracorporeal membrane oxygenation (ECMO) support
Pradip P Kamat1, Jonathan Popler, Joel Davis
1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. pkee72@hotmail.com
Insights
Flexible bronchoscopy (FB) is safe and effective for critically ill children on extracorporeal membrane oxygenation (ECMO). This procedure aids in managing respiratory complications and offers diagnostic and therapeutic benefits.
Area of Science:
- Pediatric critical care medicine
- Pulmonology
- Cardiopulmonary support
Background:
- Critically ill children on extracorporeal membrane oxygenation (ECMO) often develop respiratory issues.
- Flexible bronchoscopy (FB) can evaluate these complications, but its safety and efficacy in this patient group are not well-established.
Purpose of the Study:
- To evaluate the safety and efficacy of flexible bronchoscopy (FB) in pediatric patients receiving extracorporeal membrane oxygenation (ECMO).
Main Methods:
- Retrospective analysis of 153 flexible bronchoscopies (FBs) performed on 79 children supported by ECMO.
- Data collected included patient demographics, clinical findings, and complications.
- Chest radiographs and physiological variables were assessed before and after FB.
Main Results:
- FB was performed for airway secretion clearance (77%) and infection evaluation (17%).
- Common findings included tenacious, mucoid, and mucopurulent secretions.
- No significant changes in vital signs, ECMO parameters, or lung radiographic findings were observed post-FB. Minor post-procedural bleeding occurred in 35% of cases, resolving spontaneously.
Conclusions:
- Flexible bronchoscopy (FB) is a well-tolerated and safe procedure for critically ill pediatric patients on ECMO.
- FB provides both diagnostic and therapeutic benefits in this population.
Introduction:
Critically ill children treated with extracorporeal membrane oxygenation (ECMO) support frequently have respiratory complications amenable to evaluation by flexible bronchoscopy (FB). The safety and efficacy of FB in this setting has not been well described in children.
Methods:
Retrospective analysis of 153 FBs in 79 children treated with ECMO at a single institution from 2000 to 2008. Demographic data, clinical findings, and complications were obtained. Chest radiographs reports were evaluated prior to and following FB. Physiologic variables were compared prior to and following FB.
Results:
Seventy-nine patients underwent FB on ECMO [58 veno-venous (VV) and 21 veno-arterial (VA) ECMO], with 153 total FBs performed. Indications for FB included clearance of tenacious airway secretions (n = 118, 77%), or evaluation of suspected secondary infections with bronchoalveolar lavage (n = 26, 17%). Two patients also had surfactant instillation following secretion removal. FB was performed a median 5 days following cannulation for ECMO (range 2-14 days). Most common findings included thick secretions (n = 77, 50.3%), mucoid secretions (n = 15, 9.8%), and mucopurulent secretions (n = 28, 18.3%). No deterioration in radiographic lung findings was described post-FB. FB was not associated with any significant change in heart rate, systemic blood pressure, or temperature. No significant changes in ECMO pump flow rate or sweep gas flow was seen during or after FB. Cannula dislodgement, inadvertent extubation, fever, pneumothorax, or intraprocedural hypoxemia was not reported. Fifty-three FBs (35%) resulted in blood-tinged secretions from the endotracheal tube post-FB, which resolved spontaneously. Three patients received high frequency oscillatory ventilation (HFOV) following FB in association with mild hemorrhage.
Conclusions:
FB is a well-tolerated and safe procedure in critically ill pediatric patients on ECMO. FB may have a diagnostic as well as therapeutic benefit in such patients.
Related Concept Videos
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due to...
Oxygen Delivering System III: Tracheostomy and T-piece
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
Cardiopulmonary Resuscitation II: ACLS Airway Management
