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Related Experiment Video

Updated: May 30, 2026

Iris Fixation via External Pentagram Suturing

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Published on: May 5, 2022

Prominent decrease of superior midperipheral endothelial cell density after iris-fixated phakic intraocular lens

Jae Hoon Kim¹, Bong Joon Choi, Hyunseok Roh

¹Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul.

Journal of Refractive Surgery (Thorofare, N.J. : 1995)

|August 6, 2011

Summary

This summary is machine-generated.

Iris-fixated phakic intraocular lens (PIOL) implantation can affect corneal endothelial cell density (ECD) unevenly. Monitoring ECD in various corneal regions, particularly the superior cornea, is crucial for long-term patient eye health.

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Area of Science:

Ophthalmology
Corneal Science
Intraocular Lens Technology

Background:

Phakic intraocular lenses (PIOLs) are used to correct myopia.
Iris-fixated PIOLs are one type of lens implantation.
Endothelial cell density (ECD) is a key indicator of corneal health.

Purpose of the Study:

To assess changes in corneal endothelial cell density (ECD) after iris-fixated phakic intraocular lens (PIOL) implantation.
To compare ECD in different corneal regions (central, nasal, superior, temporal, inferior).
To evaluate the relationship between PIOL position and ECD.

Main Methods:

Study included 45 eyes with iris-fixated PIOLs and 15 control eyes.
Noncontact specular microscopy and Scheimpflug imaging were used.
Corneal ECD and endothelium-PIOL distance were measured in five regions.

Main Results:

ECD reduction after PIOL implantation was not uniform across the cornea.
Significant ECD differences were noted between superior and central/highest ECD regions.
Long-term follow-up (≥48 months) showed significant ECD changes in PIOL eyes.
In controls, superior cornea had the highest ECD; PIOL-corneal distance was greater centrally.

Conclusions:

Corneal endothelial cell density decrease is inconsistent after iris-fixated PIOL implantation.
ECD assessment should include mid-peripheral and superior corneal locations, not just the center.
This comprehensive ECD monitoring is vital for patients with iris-fixated PIOLs.