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[Cerebellar imitation synkineses].

P Trouillas1, F Brudon, J C Froment

  • 1Service de Neurologie B et Centre de recherches cliniques, Hôpital Neurologique, Lyon.

Revue Neurologique
|January 1, 1990
PubMed
Summary
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Imitation synkinesis, involuntary movements mirroring voluntary ones, was observed in patients with cerebellar atrophy. This suggests a cerebellar origin due to impaired inhibition, particularly on the dominant side.

Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Autosomal dominant pure cortical cerebellar atrophy is a rare genetic disorder affecting cerebellar function.
  • Imitation synkinesis, the involuntary mirroring of movements, has been documented but its precise origin is debated.

Observation:

  • Two family members with hereditary cerebellar atrophy displayed hand and foot imitation synkinesis when the opposite limb moved.
  • This phenomenon was more pronounced with alternating hand movements and occurred predominantly on the right side.
  • Electromyography revealed a delay in synkinesis onset, suggesting a cerebellar processing lag.

Findings:

  • Imitation synkinesis was also present in sporadic cerebellar atrophy and post-surgical cerebellar vermis injury cases.
  • Neurological examinations and somatosensory evoked potentials were normal in genetic cases, ruling out pyramidal or sensory pathway involvement.

Related Experiment Videos

  • The findings strongly support a cerebellar origin for imitation synkinesis.

    • Implications:

    • Impaired cerebellar inhibition, potentially in the paleo- and/or neo-cerebellum, may cause imitation synkinesis.
    • The observed right-sided predominance suggests stronger cerebellar inhibition on the dominant side, suppressing archaic synkinetic movements.
    • Understanding this mechanism could offer insights into cerebellar function and motor control disorders.