Outpatient management of primary hyperparathyroidism

Primary hyperparathyroidism is the most common cause of hypercalcemia in an outpatient setting. Most patients are asymptomatic with mild hypercalcemia and only require periodic follow-up. Symptomatic patients and those with end-organ damage should undergo surgery according to the National Institutes of Health guidelines. No medical therapy has been approved for treatment of this disorder. Treatment with bisphosphonate, calcimimetic drugs, or alcohol ablation techniques has been used in select patients.