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Updated: May 30, 2026

Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell
Cristina Muniesa1, Ramon M Pujol, M Teresa Estrach
1Department of Dermatology, Hospital de Viladecans, Barcelona, Spain.
Background:
Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL), leg type can eventually disseminate to extracutaneous sites including testes. In addition, patients with testicular lymphoma can develop specific skin involvement.
Objective:
We sought to describe similarities between PCDLBCL, leg type and testicular B-cell lymphoma affecting the skin.
Methods:
We report two cases with typical clinicopathological and immunophenotypical features of leg type lymphoma occurring simultaneously with a testicular B-cell lymphoma. We also report an additional case of PCDLBCL, leg type with secondary testicular involvement.
Results:
All cases presented with typical red tumors exclusively located on the legs. Histologically, all cases showed a diffuse nonepidermotropic infiltrate composed of large blastic cells mainly centroblastic type. Phenotype showed strong positivity for Bcl-2, MUM-1, and FOXP1. Epstein-Barr virus stains and CD30 were negative in the 3 cases. In all cases the testicular infiltration showed the same pathological and phenotypical changes to those observed in the skin.
Limitations:
This was a retrospective case series study.
Conclusion:
Skin involvement by testicular B-cell lymphomas and PCDLBCL, leg type are indistinguishable on the basis of pathologic and immunophenotypical features, therefore specific investigation and clinic correlation are needed.
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