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Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and oligoarthritis
Julien Castioni1, Anca Mihaescu, Alexander-Kaï So
1Service de médecine interne, CHU vaudois, 1011 Lausanne, Switzerland. julien.castioni@chuv.ch
Abstract:
A 24-year-old woman who had sinus histiocytosis with massive lymphadenopathy (SHML, Rosai-Dorfman disease) also had oligoarthritis. We found only four previously reported cases of SHML with clinical joint disease. The clinical picture may suggest rheumatoid arthritis or a spondylarthropathy with peripheral joint involvement. SHML should be considered routinely among the differential diagnoses in young patients with arthritis and large lymphadenopathies. There is no consensus regarding the treatment. In our patient, conventional disease-modifying antirheumatic drugs followed by 3 months of adalimumab then 3 months of etanercept had no effect on the symptoms.
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