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Estrogen sulfotransferase inhibits adipocyte differentiation

Taira Wada1, Chibueze A Ihunnah, Jie Gao

  • 1Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

Molecular Endocrinology (Baltimore, Md.)
|August 6, 2011
PubMed
Summary

Estrogen sulfotransferase (EST) inhibits adipocyte differentiation by activating ERK1/2 MAPK and blocking insulin signaling. This enzyme is a key negative regulator of adipogenesis, impacting fat cell development.

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