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Evolution of laboratory values in patients with Kawasaki disease

Adriana H Tremoulet1, Sonia Jain, Divya Chandrasekar

  • 1Department of Pediatrics, University of California, San Diego and Rady Children's Hospital San Diego, La Jolla, CA 92093, USA. atremoulet@ucsd.edu

The Pediatric Infectious Disease Journal
|August 6, 2011
PubMed

Insights

Kawasaki disease (KD) laboratory values change predictably during illness and after intravenous immunoglobulin (IVIG) treatment. Tracking these dynamic changes aids in diagnosing KD and assessing coronary artery outcomes.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Clinical Pathology

Background:

  • Diagnosis of Kawasaki disease (KD) relies on clinical laboratory studies per American Heart Association guidelines.
  • Detailed evolution of laboratory values during KD illness has not been previously reported.

Purpose of the Study:

  • To characterize the evolution of clinical laboratory values in KD patients before and after intravenous immunoglobulin (IVIG) treatment.
  • To correlate laboratory value changes with treatment response and coronary artery outcomes.

Main Methods:

  • Analysis of laboratory values from 380 KD patients at acute, subacute, and convalescent phases.
  • Stratification of results by IVIG response and coronary artery outcome.

Main Results:

  • White blood cell count, ESR, and CRP peaked in the acute phase; platelet count peaked in the subacute phase; lymphocytes and eosinophils peaked in the convalescent phase.
  • Patients with coronary artery aneurysms showed higher WBC in the subacute phase and higher ESR in subacute and convalescent phases.

Conclusions:

  • Consistent evolution of laboratory values is observed in KD before and after treatment.
  • Understanding dynamic laboratory changes aids physicians in diagnosing KD using American Heart Association guidelines.
Abstract

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