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Updated: May 30, 2026

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Published on: June 13, 2025
Diagnostic analysis of patients with essential hypertension using association rule mining
A Mi Shin1, In Hee Lee, Gyeong Ho Lee
1Department of Medical Informatics, School of Medicine, Keimyung University, Daegu, Korea.
Insights
Essential hypertension is strongly linked to non-insulin dependent diabetes mellitus and cerebral infarction. Association rule mining effectively identified these comorbidities in a large patient database.
Area of Science:
- Medical Informatics
- Data Mining
- Cardiovascular Epidemiology
Background:
- Essential hypertension is a prevalent cardiovascular condition.
- Understanding comorbidities is crucial for effective patient management.
- Association Rule Mining (ARM) offers a method to uncover hidden relationships in large datasets.
Purpose of the Study:
- To analyze patient records for essential hypertension using Association Rule Mining (ARM).
- To identify significant comorbidities associated with essential hypertension.
Main Methods:
- Utilized Apriori modeling within the Clementine 12.0 program for ARM analysis.
- Extracted and analyzed diagnostic data from 5,022 patients with essential hypertension (ICD code, I10).
Main Results:
- Identified strong associations between essential hypertension, non-insulin dependent diabetes mellitus (NIDDM), and cerebral infarction.
- NIDDM showed a support of 35.15% and confidence of 100% with essential hypertension.
- Cerebral infarction demonstrated a support of 21.21% and confidence of 100% with essential hypertension.
Conclusions:
- Essential hypertension is significantly associated with NIDDM and cerebral infarction.
- ARM is a practical tool for exploring comorbidities in large clinical databases.
- Findings highlight potential targets for integrated care strategies.
Objectives:
The purpose of this study was to analyze the records of patients diagnosed with essential hypertension using association rule mining (ARM).
Methods:
Patients with essential hypertension (ICD code, I10) were extracted from a hospital's data warehouse and a data mart constructed for analysis. Apriori modeling of the ARM method and web node in the Clementine 12.0 program were used to analyze patient data.
Results:
Patients diagnosed with essential hypertension totaled 5,022 and the diagnostic data extracted from those patients numbered 53,994. As a result of the web node, essential hypertension, non-insulin dependent diabetes mellitus (NIDDM), and cerebral infarction were shown to be associated. Based on the results of ARM, NIDDM (support, 35.15%; confidence, 100%) and cerebral infarction (support, 21.21%; confidence, 100%) were determined to be important diseases associated with essential hypertension.
Conclusions:
Essential hypertension was strongly associated with NIDDM and cerebral infarction. This study demonstrated the practicality of ARM in co-morbidity studies using a large clinic database.
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