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Related Experiment Video

Updated: May 30, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Yin-yang strategy: proposing a new, effective, repeatable, sequential therapy for psoriasis.

Tina Bhutani1, Kristine B Zitelli, John Koo

  • 1University of California San Francisco, Psoriasis and Skin Treatment Center, San Francisco, CA 94118, USA. tinabhutanimd@gmail.com

Journal of Drugs in Dermatology : JDD
|August 6, 2011
PubMed
Summary

This study proposes a sequential topical therapy for psoriasis, using clobetasol spray followed by calcitriol ointment. This approach effectively manages both acute flares and chronic phases of psoriasis with minimal risks.

Related Experiment Videos

Last Updated: May 30, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory skin condition with distinct acute (flaring) and chronic (indolent) phases.
  • Effective psoriasis management requires addressing both the acute inflammatory symptoms and long-term maintenance.
  • Current therapies may not optimally address the sequential nature of psoriasis phases.

Purpose of the Study:

  • To propose and evaluate a novel sequential topical therapy for psoriasis.
  • To address the need for rapid control of acute flares and safe long-term maintenance.
  • To investigate the efficacy and safety of a clobetasol-calcitriol sequential regimen.

Main Methods:

  • A sequential topical treatment strategy was proposed.
  • Phase 1: Clobetasol (Clobex®) spray applied for one month to manage acute inflammation.
  • Phase 2: Calcitriol (Vectical®) ointment applied for the subsequent month for maintenance.

Main Results:

  • The proposed sequential therapy aims for high efficacy in managing psoriasis.
  • The regimen is designed to be reliable for both acute and chronic phases.
  • Minimal local and systemic adverse risks are anticipated with this approach.

Conclusions:

  • A sequential topical therapy combining clobetasol spray and calcitriol ointment offers a promising treatment option for psoriasis.
  • This strategy effectively targets both the acute and chronic phases of the disease.
  • The proposed regimen provides a safe and reliable approach with a favorable risk profile.