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Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Inheritance of Chromatin Structures

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: May 30, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

Epigenetic biomarkers.

Timothy A Chan¹, Stephen B Baylin

¹Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. chant@mskcc.org

Current Topics in Microbiology and Immunology

|August 6, 2011

Summary

This summary is machine-generated.

Cancer epigenetics involves DNA methylation and chromatin changes driving malignancy. These epigenetic biomarkers predict treatment response and aid in developing targeted cancer therapies.

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Last Updated: May 30, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Area of Science:

Cancer Biology
Epigenetics
Genomics

Background:

Cancer development is linked to significant epigenetic alterations in DNA methylation and chromatin modifications.
These epigenetic changes influence tumorigenesis and cancer cell pathogenicity.
Identifying these alterations as biomarkers is crucial for cancer diagnosis and prognosis.

Purpose of the Study:

To explore the role of epigenetic changes in cancer development.
To highlight the clinical utility of epigenetic alterations as cancer biomarkers.
To discuss the impact of global analysis strategies on understanding cancer epigenetics.

Main Methods:

Analysis of large-scale DNA methylation patterns.
Assessment of post-translational chromatin modifications.
Application of global epigenomic analysis strategies.

Main Results:

Epigenetic aberrations are fundamental to human malignancy development.
Epigenetic biomarkers can predict sensitivity to chemotherapy and targeted therapies.
Global analysis strategies enhance the understanding of cancer epigenomes.

Conclusions:

Epigenetic modifications are key drivers of cancer progression.
Epigenetic biomarkers offer significant clinical utility for personalized cancer treatment.
Continued research in cancer epigenomics promises improved diagnostics and therapeutics.