Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of technology and AI tools in type 2 diabetes.

Best practice & research. Clinical endocrinology & metabolism·2026
Same author

Obstructive sleep apnea: Proposed scoring system.

World journal of methodology·2026
Same author

A multicentre survey of liver fibrosis burden in type 2 diabetes in India: the DiaFib-Liver Study.

The Lancet regional health. Southeast Asia·2026
Same author

Semaglutide Hype or Hope: Evidence-based Review in Diabesity.

The Journal of the Association of Physicians of India·2026
Same author

Burden of Obesity in India: Need for Policy Changes to Attain Highest Possible Level of Health and Well-Being.

Clinical obesity·2026
Same author

Optimizing Continuous Glucose Monitoring Adoption in India: From Current Challenges to Future Solutions.

Diabetes therapy : research, treatment and education of diabetes and related disorders·2026

Related Experiment Video

Updated: May 30, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Continuous insulin infusion systems in type 2 diabetes.

Jothydev Kesavadev1

  • 1Jothydev's Diabetes & Research Centre, Trivandrum 695032, India.

The Journal of the Association of Physicians of India
|August 9, 2011
PubMed
Summary

Insulin pumps offer improved quality of life for type 2 diabetes patients by mimicking natural insulin secretion. Continuous subcutaneous insulin infusion (CSII) with continuous glucose monitoring (CGM) aids lifestyle adjustments based on glucose patterns.

Area of Science:

  • Endocrinology
  • Diabetes Management
  • Medical Devices

Background:

  • Traditional insulin delivery methods like syringes and pens have limitations including dosage errors and patient discomfort.
  • Insulin pumps offer a more advanced method for insulin delivery, aiming to replicate physiological insulin secretion patterns.
  • Despite being available in India for a decade, insulin pumps remain underutilized due to high costs and limited user experience.

Observation:

  • Continuous subcutaneous insulin infusion (CSII) presents significant, previously unrecognized benefits for select type 2 diabetes mellitus patients.
  • The integration of insulin pumps with continuous glucose monitoring (CGM) systems provides valuable therapeutic insights.
  • Patient data from CGM systems enables personalized lifestyle modifications in response to observed glycemic patterns.

More Related Videos

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device
07:55

A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device

Published on: January 26, 2010

Related Experiment Videos

Last Updated: May 30, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device
07:55

A Multi-Parametric Islet Perifusion System within a Microfluidic Perifusion Device

Published on: January 26, 2010

Findings:

  • Evidence suggests CSII is a beneficial therapeutic option for managing type 2 diabetes.
  • Pumps combined with CGM systems empower patients to actively manage their condition.
  • Improved glycemic control and quality of life are potential outcomes of using insulin pump therapy.

Implications:

  • Wider adoption of insulin pump technology, particularly CSII with CGM, could enhance diabetes care in India.
  • Addressing cost barriers is crucial for increasing accessibility and utilization of advanced insulin delivery systems.
  • Further research and patient education are needed to fully leverage the benefits of insulin pump therapy for type 2 diabetes management.