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Chemical genetics-based target identification in drug discovery.

Feng Cong1, Atwood K Cheung, Shih-Min A Huang

  • 1Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA. feng.cong@novartis.com

Annual Review of Pharmacology and Toxicology
|August 9, 2011
PubMed
Summary

Chemical genetics offers an unbiased approach to discovering new drug targets by screening entire pathways. Reliable methods for identifying the specific targets of small molecules are crucial for realizing its full potential in drug discovery.

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