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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...

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Related Experiment Video

Updated: May 30, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Wound degradomics - current status and future perspectives.

Olivia Hermes1, Pascal Schlage, Ulrich auf dem Keller

  • 1Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland.

Biological Chemistry
|August 9, 2011
PubMed
Summary

Proteases regulate skin healing by modifying extracellular matrix and proteins. Understanding protease interactions is key to treating chronic wounds effectively.

Area of Science:

  • Dermatology
  • Biochemistry
  • Molecular Biology

Background:

  • Proteases are crucial for regulating extracellular matrix and protein activity during skin wound healing.
  • Dysregulation of protease activity at wound sites significantly contributes to chronic wound pathology.
  • Existing research provides insights into individual protease roles in skin repair.

Purpose of the Study:

  • To address the challenge of integrating knowledge on individual proteases into a systems-level understanding of wound healing.
  • To elucidate complex interactions between proteolytic enzymes, their inhibitors, and substrates in cutaneous wound healing.
  • To present novel approaches for studying protease systems in wound healing research.

Main Methods:

  • Review and synthesis of existing research on proteases in wound healing.

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Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

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Last Updated: May 30, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

  • Conceptualization of systems-level approaches for studying protease interactions.
  • Identification of novel methodologies for investigating proteolytic networks in skin repair.

    • Main Results:

    • Highlighting the critical role of proteases in all stages of cutaneous wound healing.
    • Identifying the disturbance of proteolytic activity as a major factor in chronic wound development.
    • Proposing a framework for understanding protease, inhibitor, and substrate interactions on a system-wide level.

    Conclusions:

    • A comprehensive, systems-level understanding of protease dynamics is essential for advancing chronic wound treatment.
    • Novel approaches are needed to integrate current knowledge and investigate complex proteolytic interactions.
    • Further research focusing on these interactions will be pivotal for improving skin integrity reestablishment upon injury.