Related Experiment Video
Updated: May 30, 2026

06:56
Influenza Virus Propagation in Embryonated Chicken Eggs
Published on: March 19, 2015
Pathogenesis of influenza: virus-host interactions
Alexandra Godlee1, Mark H Almond, Tao Dong
1National Heart and Lung Institute, Imperial College London, London, UK. alexandra.godlee07@imperial.ac.uk
Expert Review of Anti-Infective Therapy
|August 9, 2011
Summary
This article summarizes a 2011 conference on influenza virus and host interactions. Key themes discussed included insights into pandemic H1N1 and avian H5N1 influenza viruses.
Area of Science:
- Molecular and Cellular Biology
- Virology
- Immunology
Background:
- Keystone Symposia, a non-profit organization, has convened global scientists since 1972.
- The 2011 meeting focused on influenza virus and host interactions, occurring during a period of H5N1 emergence.
- The conference followed the first influenza pandemic in 40 years, providing timely insights.
Framework:
- The conference brought together over 200 virologists and immunologists.
- Discussions centered on the interactions between influenza viruses and their hosts.
- The event was held in Hong Kong, a relevant location due to H5N1 avian flu concerns.
Implementation:
- Organized by Siamon Gordon, Malik Peiris, and Kanta Subbarao.
- The meeting provided a platform for discussing recent advancements and challenges in influenza research.
- Focus on recurring themes from the week-long scientific exchange.
Implications:
- The discussions offered valuable insights into both pandemic H1N1 and avian H5N1 influenza.
- Understanding virus-host interactions is crucial for pandemic preparedness and response.
- The article highlights key takeaways from the scientific exchange on influenza viruses.
More Related Videos
Related Concept Videos
Influenza
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Inhibitors Of Virion Release
Viral replication and dissemination rely on efficient mechanisms for host cell entry, genome replication, assembly, and release. Influenza viruses, such as types A and B, are negative-sense single-stranded RNA viruses with a segmented genome, that depend on two critical surface glycoproteins to carry out these processes: hemagglutinin (HA) and neuraminidase (NA). HA initiates infection by binding to sialic acid residues on the surface of host epithelial cells, facilitating receptor-mediated...
Viral Recombination
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of many...
Leaky Scanning
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...

