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Updated: May 30, 2026

05:19
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Can the rat be used as a valid model of human esophageal adenocarcinoma?
A Hindmarsh1, N Belshaw, S Mehta
1Department of Upper GI Surgery, Norfolk and Norwich University Hospital, Norwich, UK. andrewhindmarsh@hotmail.com
Abstract:
Animal models of Barrett's metaplasia and esophageal adenocarcinoma are important to further characterize the disease and test potential therapies. This paper reviews the development of the surgical model of esophageal adenocarcinoma in the rat and considers whether this model provides a biologically accurate representation of Barrett's esophagus and esophageal adenocarcinoma in humans.

