Differences in left ventricular diastolic dysfunction between eccentric and concentric left ventricular hypertrophy
H Masugata1, S Senda, M Inukai
1Department of Integrated Medicine, Kagawa University, Kagawa, Japan. masugata@med.kagawa-u.ac.jp
The Journal of International Medical Research
|August 9, 2011
Summary
Concentric left ventricular hypertrophy (LVH) indicates worse diastolic dysfunction than eccentric LVH in hypertensive patients, even with similar LV mass index. This finding highlights differences in diastolic function despite comparable degrees of LVH.
Area of Science:
- Cardiology
- Echocardiography
- Hypertension Research
Background:
- Left ventricular hypertrophy (LVH) presents as eccentric or concentric types.
- Hypertension is a common cause of LVH, impacting cardiac structure and function.
- Understanding the functional implications of different LVH types is crucial for patient management.
Purpose of the Study:
- To compare left ventricular (LV) diastolic function in age-matched hypertensive patients with eccentric versus concentric LVH.
- To investigate whether the type of LVH influences the severity of diastolic dysfunction, independent of LV mass.
Main Methods:
- Echocardiography was employed to assess LV mass index (LVMI) as a measure of LVH.
- LV diastolic function was evaluated using transmitral flow velocities (E/A ratio) and mitral annular velocities (e').
- The E/e' ratio was calculated to further assess diastolic function.
Main Results:
- No significant differences were observed in LVMI, E/A ratio, or e' between patients with eccentric and concentric LVH.
- The E/e' ratio was significantly higher in the concentric LVH group (13.4 ± 5.4) compared to the eccentric LVH group (11.1 ± 3.6).
- A higher E/e' ratio suggests more impaired LV diastolic function.
Conclusions:
- Concentric LVH in hypertensive patients is associated with more severe LV diastolic dysfunction than eccentric LVH.
- Diastolic dysfunction severity may differ between LVH types even when LVMI is similar.
- These findings suggest that the geometric pattern of LVH is an important determinant of diastolic function in hypertension.
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