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Updated: May 30, 2026

High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing
Published on: May 21, 2020
The rise of yeast population genomics
Gianni Liti1, Joseph Schacherer
1Centre for Genetics and Genomics, University of Nottingham, Nottingham NG7 2UH, UK.
Abstract:
Genome sequences of multiple individuals are essential to determine the forces shaping sequence variation as well as to understand the relationship between genotype and phenotype. Because of their wide ecological, geographical and genetic diversity, yeast species represent an ideal model system for population genomics. Recently, there has been a renewed interest in characterizing the genetic diversity within yeast species such as Saccharomyces cerevisiae and Saccharomyces paradoxus. Here, we review recent progress in the exploration of the intraspecific diversity using large collections of yeast isolates. These recent large-scale polymorphism surveys have increased our understanding of the population structures as well as the evolutionary history of the species. In addition, these resources represent a powerful framework for dissecting the relationship between genotype and phenotype.
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