Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of a Key Hemagglutinin Mutation Mediating Antibody Escape in Influenza A(H1N1)pdm09 Viruses.

Viruses·2026
Same author

Route-Dependent Proteomic Landscape in Mouse Models of Carbon Tetrachloride-Induced Hepatic Fibrosis.

Journal of proteome research·2026
Same author

Trajectories of Autism Symptoms and Overlapping Patterns in a Chinese Cohort From 18 to 36 Months.

Autism research : official journal of the International Society for Autism Research·2026
Same author

Ultrahigh energy storage density and efficiency in AgNbO<sub>3</sub>-based ceramics by percolating interaction between antipolar regions and defect pairs.

Nature communications·2026
Same author

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion.

Nature communications·2025
Same author

Corrigendum to "High-precision in-situ determination of silver isotopes in argentiferous minerals by fsLA-MC-ICP-MS" [Analytica Chimica Acta 1377 (2025) 344657].

Analytica chimica acta·2025

Related Experiment Video

Updated: May 30, 2026

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light
11:36

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light

Published on: February 10, 2017

Pre and postsynaptic roles for Drosophila CASK.

Kaiyun Chen1, David E Featherstone

  • 1Biological Sciences, University of Illinois at Chicago, Chicago IL, USA.

Molecular and Cellular Neurosciences
|August 9, 2011
PubMed
Summary

Calcium/calmodulin-dependent serine protein kinase (CASK) is crucial for synapse function. Loss of CASK impacts synaptic transmission and glutamate receptor stability, highlighting its role in neuronal communication.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • CASK (calcium/calmodulin-dependent serine protein kinase) is implicated in cell-cell junction formation, particularly at synapses.
  • Understanding CASK's precise role in synapse development and function is essential for comprehending neural circuit assembly.

Purpose of the Study:

  • To investigate the function of Drosophila CASK in glutamatergic neuromuscular junctions (NMJs).
  • To determine the effects of manipulating CASK expression on synapse formation, structure, and function.

Main Methods:

  • Functional and morphological analysis of Drosophila embryonic and larval NMJs.
  • Pan-cellular and tissue-specific manipulation of CASK expression.

Main Results:

More Related Videos

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
10:13

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains

Published on: November 6, 2017

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
06:05

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

Related Experiment Videos

Last Updated: May 30, 2026

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light
11:36

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light

Published on: February 10, 2017

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
10:13

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains

Published on: November 6, 2017

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
06:05

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

  • Presynaptic CASK loss reduced evoked synaptic transmission, spontaneous events, and vesicle cycling, with fewer synapses but unchanged NMJ size.
  • Postsynaptic CASK loss decreased spontaneous current amplitudes and glutamate-gated currents.
  • Loss of postsynaptic CASK specifically affected GluRIIA-containing glutamate receptors, while GluRIIB receptors remained unaffected.

Conclusions:

  • Drosophila CASK localizes to both pre- and postsynaptic membranes.
  • CASK plays distinct roles in presynaptic neurotransmission and postsynaptic glutamate receptor stability.
  • CASK is critical for maintaining the integrity and function of glutamatergic synapses through subtype-specific receptor regulation.