Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute fluoride toxicity. Pathophysiology and management.

M E McIvor

    Drug Safety
    |March 1, 1990
    PubMed
    Summary

    Acute inorganic fluoride poisoning causes severe burns and disrupts homeostasis by binding essential cations, leading to hypocalcemia. Treatment focuses on preventing absorption, supporting the patient, and enhancing fluoride removal.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    SPICED TEAS manuscript. Study of Pacemaker and Implantable CardiovErter Defibrillator Triggering by Electronic Article Surveillance devices.

    Pacing and clinical electrophysiology : PACE·1999
    Same author

    Interactions between cardiac pacemakers and antishoplifting security systems.

    The New England journal of medicine·1998
    Same author

    Study of Pacemaker and Implantable Cardioverter Defibrillator Triggering by Electronic Article Surveillance Devices (SPICED TEAS)

    Pacing and clinical electrophysiology : PACE·1998
    Same author

    Environmental electromagnetic interference from electronic article surveillance devices: interactions with an ICD.

    Pacing and clinical electrophysiology : PACE·1995
    Same author

    Clinical effects and utility of intracoronary diltiazem.

    Catheterization and cardiovascular diagnosis·1995
    Same author

    New techniques for guiding catheter management during directional coronary atherectomy.

    Catheterization and cardiovascular diagnosis·1993

    Area of Science:

    • Toxicology
    • Environmental Health

    Background:

    • Acute inorganic fluoride intoxication poses significant health risks.
    • Fluoride's corrosive and metabolic effects disrupt physiological systems.

    Purpose of the Study:

    • To outline the mechanisms of acute inorganic fluoride toxicity.
    • To describe therapeutic strategies for managing fluoride poisoning.

    Main Methods:

    • Review of physiological effects of inorganic fluoride.
    • Analysis of therapeutic interventions for acute fluoride poisoning.

    Main Results:

    • Fluoride acts as a corrosive acid and a metabolic poison.
    • It causes hypocalcemia, inhibits enzymes (e.g., Na(+)-K(+)-ATPase), and can lead to hyperkalemia.
    • Therapy involves preventing absorption, supporting homeostasis, and enhancing elimination.

    Conclusions:

    • Prompt and comprehensive management is crucial for improving prognosis in acute fluoride poisoning.
    • Supportive care for 24 hours significantly improves patient outcomes, though delayed toxicity is possible.

    Related Experiment Videos