Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adverse reactions to plasma volume expanders.

M M Fisher1, P W Brady

  • 1Intensive Therapy Unit, Royal North Shore Hospital of Sydney, St Leonards, New South Wales, Australia.

Drug Safety
|March 1, 1990
PubMed
Summary

Plasma volume expanders restore blood volume but can rarely cause anaphylactoid reactions. Hydroxyethyl starch persistence raises carcinogen concerns, though evidence is lacking.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Canadian Liver Foundation celebrates 50 years of commitment to hepatology.

Canadian liver journal·2022
Same author

Preventing hepatitis B in health care workers.

Canadian family physician Medecin de famille canadien·2011
Same author

Follow-up after anaesthetic anaphylaxis.

Acta anaesthesiologica Scandinavica·2010
Same author

"Anaortic" off-pump coronary artery bypass grafting significantly reduces neurological complications compared to off-pump and conventional on-pump surgery with aortic manipulation.

The Thoracic and cardiovascular surgeon·2010
Same author

The investigation of bronchospasm during induction of anaesthesia.

Acta anaesthesiologica Scandinavica·2009
Same author

On the origin and specificity of antibodies to neuromuscular blocking (muscle relaxant) drugs: an immunochemical perspective.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2009

Area of Science:

  • Medical science
  • Pharmacology
  • Critical care medicine

Background:

  • Plasma volume expanders are crucial for restoring blood volume in various clinical settings.
  • Available expanders carry a risk of rare anaphylactoid reactions, particularly in non-shocked patients.
  • Mechanisms of these reactions vary and are not typically IgE-mediated.

Purpose of the Study:

  • To review the efficacy and safety of plasma volume expanders.
  • To discuss potential adverse effects, including anaphylactoid reactions, hemostatic, and renal effects.
  • To address concerns regarding the long-term effects of hydroxyethyl starch, including carcinogenicity.

Main Methods:

  • Literature review of plasma volume expanders.
  • Analysis of reported adverse events and safety data.
  • Evaluation of pharmacokinetic properties and long-term safety concerns.

Main Results:

  • Plasma volume expanders effectively restore blood volume.
  • Anaphylactoid reactions are rare, especially in shocked patients.
  • Hydroxyethyl starch exhibits persistence in the body, prompting carcinogenicity concerns, yet lacking supporting evidence.

Conclusions:

  • Plasma volume expanders are generally safe and effective for blood volume restoration.
  • Vigilance for rare anaphylactoid reactions is necessary.
  • Long-term safety of hydroxyethyl starch requires continued monitoring, despite current lack of carcinogenic evidence.

Related Experiment Videos