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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genetic Material01:20

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.

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Updated: May 30, 2026

Microbial Communities in Nature and Laboratory - Interview
29:13

Microbial Communities in Nature and Laboratory - Interview

Published on: May 28, 2007

The genome and its implications.

Santuza M Teixeira1, Najib M El-Sayed, Patrícia R Araújo

  • 1Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Advances in Parasitology
|August 9, 2011
PubMed
Summary
This summary is machine-generated.

The Trypanosoma cruzi genome, though complex and repetitive, provides crucial insights into parasite biology. This genomic data is vital for developing new strategies to combat Chagas disease.

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Last Updated: May 30, 2026

Microbial Communities in Nature and Laboratory - Interview
29:13

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Published on: May 28, 2007

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

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10:19

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Area of Science:

  • Genomics
  • Parasitology
  • Molecular Biology

Background:

  • Trypanosoma cruzi exhibits significant population heterogeneity across domestic and sylvatic cycles.
  • Understanding the genetic makeup of T. cruzi is essential for controlling Chagas disease.

Purpose of the Study:

  • To present the genome sequencing of the T. cruzi CL Brener clone.
  • To analyze the unique genomic features of T. cruzi, including its repetitive nature and gene organization.

Main Methods:

  • Whole-genome sequencing of the T. cruzi CL Brener clone.
  • Bioinformatic analysis to assemble and characterize the genome.
  • Comparative genomic approaches to understand genetic diversity.

Main Results:

  • The T. cruzi genome is approximately 110Mb with nearly 50% repetitive content, posing assembly challenges.
  • Genes are organized into peculiar polycistronic transcription units, and surface protein gene families are massively expanded.
  • The hybrid nature of the CL Brener clone necessitated sequencing of both haplotypes.

Conclusions:

  • The T. cruzi genome sequence is a foundational resource for parasite research.
  • Ongoing genomic and transcriptomic analyses are crucial for understanding T. cruzi diversity.
  • This knowledge is instrumental in developing novel interventions against Chagas disease.