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09:22
Sectioning Mammary Gland Whole Mounts for Lesion Identification
Published on: July 24, 2017
Complex mammary adenoma with sebaceous differentiation in a dog
A G Kurilj1, M Hohšteter, A Beck
1Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia. agudan@vef.hr
Journal of Comparative Pathology
|August 9, 2011
Summary
A rare canine mammary tumor exhibited sebaceous metaplasia, a change where sebaceous gland cells form within the tumor. This complex adenoma highlights unusual differentiation in canine mammary gland neoplasms.
Area of Science:
- Veterinary Pathology
- Canine Neoplasia
- Mammary Gland Tumors
Background:
- Complex adenomas are common mammary tumors in female dogs.
- Sebaceous metaplasia is a less common differentiation pathway in these tumors.
Observation:
- A 9-year-old Miniature Pinscher presented with a complex adenoma of the left fourth mammary gland.
- Histopathological examination revealed tubular and ductular structures with myoepithelial-like cells and sebaceous gland components.
Findings:
- Well-differentiated sebocytes, identified by Sudan III staining, were surrounded by basaloid cells.
- Immunohistochemistry showed cytokeratin AE1/AE3 expression in both epithelial and sebaceous-differentiated cells.
Implications:
- This case expands the understanding of differentiation potential in canine mammary adenomas.
- It underscores the importance of detailed histopathological and immunohistochemical analysis for accurate diagnosis.
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