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Related Experiment Video

Updated: May 30, 2026

Three-Dimensional Acoustic Assembly Device for Mass Manufacturing of Cell Spheroids

Three-Dimensional Acoustic Assembly Device for Mass Manufacturing of Cell Spheroids

Published on: October 13, 2023

The assembly of cell-encapsulating microscale hydrogels using acoustic waves.

Feng Xu¹, Thomas D Finley, Muge Turkaydin

¹Demirci Bio-Acoustic-MEMS in Medicine Laboratory, Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

|August 9, 2011

Summary

This study introduces a novel acoustic assembler for rapidly and non-invasively organizing microgels. This breakthrough technology maintains high cell viability and offers efficient assembly for tissue engineering and drug screening applications.

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Last Updated: May 30, 2026

Three-Dimensional Acoustic Assembly Device for Mass Manufacturing of Cell Spheroids

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Published on: October 13, 2023

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

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Published on: July 18, 2018

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

Area of Science:

Biotechnology
Biomaterials Science
Regenerative Medicine

Background:

Microscale hydrogels are crucial for tissue engineering and regenerative medicine.
Current methods for assembling microgels into 3D constructs are often slow, destructive, or inefficient.
There is a need for rapid, non-invasive, and high-throughput microgel assembly techniques.

Purpose of the Study:

To develop a simple, non-invasive acoustic assembler for microgels.
To demonstrate the assembler's efficiency and ability to maintain cell viability.
To assess the assembler's versatility with various microgel sizes, shapes, and microdroplet volumes.

Main Methods:

Development of a non-invasive acoustic assembler.
Testing the assembler with microbeads (50 µm, 100 µm) and diverse microgel shapes (cubes, lock-and-key, tetris, saw).
Assembly of microgels within microdroplets of varying volumes (10 µL, 20 µL, 40 µL, 80 µL).

Main Results:

Successful non-invasive assembly of microgels in seconds.
Maintained high cell viability (>93%) in cell-encapsulating microgels.
Demonstrated effectiveness across different microgel sizes, shapes, and microdroplet volumes.

Conclusions:

The developed acoustic assembler provides a rapid and non-invasive method for microgel assembly.
This technology shows significant potential as an enabling tool for tissue engineering, regenerative medicine, and high-throughput screening.
Acoustic assembly offers a promising advancement over existing microgel manipulation techniques.