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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Targeted long-term venous occlusion using pulsed high-intensity focused ultrasound combined with a pro-inflammatory

Yufeng Zhou1, Jasmine Zia, Cinderella Warren

  • 1Division of Engineering Mechanics, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.

Ultrasound in Medicine & Biology
|August 9, 2011
PubMed

Insights

A new ultrasound therapy shows promise for treating esophageal varices. This method uses focused ultrasound and microbubbles to create long-term vascular occlusion, potentially improving outcomes for cirrhotic patients.

Area of Science:

  • Biomedical Engineering
  • Gastroenterology
  • Vascular Biology

Background:

  • Esophageal and gastric varices pose significant risks for cirrhotic patients.
  • Current treatments like endoscopic band ligation and sclerotherapy have limitations, including frequent sessions and adverse effects.

Purpose of the Study:

  • To investigate a novel method for inducing long-term vascular occlusion in veins.
  • To evaluate the efficacy of pulsed high-intensity focused ultrasound combined with microbubbles and pro-inflammatory agents for vascular thrombosis.

Main Methods:

  • Utilized pulsed high-intensity focused ultrasound (9 MPa) on rabbit auricular veins.
  • Administered intravenous ultrasound microbubbles followed by local injection of fibrinogen and pro-inflammatory agents (ethanol, cyanoacrylate, or morrhuate sodium).

Main Results:

  • The novel method successfully induced acute and long-term complete vascular occlusions.
  • Combination of pro-inflammatory agent with fibrinogen was effective in achieving sustained occlusion.

Conclusions:

  • This ultrasound-based approach offers a potential new therapy for esophageal and gastric varices.
  • Further translational studies are required to determine clinical applicability.

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