Related Experiment Video
Updated: May 30, 2026

19:15
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Maternal active smoking and newborn body composition.
M P Samper1, A Jiménez-Muro, I Nerín
1Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
Early Human Development
|August 9, 2011
Summary
Maternal smoking during pregnancy reduces newborn size and affects body composition, with lean body mass appearing more impacted than fat. This highlights smoking as a significant factor in fetal growth impairment.
Area of Science:
- Neonatal anthropometry
- Maternal-fetal medicine
- Public health
Background:
- Maternal smoking during pregnancy is a known risk factor for reduced birth size.
- Limited research has comprehensively assessed changes in neonatal anthropometry due to maternal smoking.
Purpose of the Study:
- To evaluate differences in neonatal anthropometry and body composition between newborns of smoking and non-smoking mothers.
- To determine if these anthropometric differences impact the proportional distribution of body mass.
Main Methods:
- A cohort of 1216 Caucasian mothers and their full-term singleton newborns were studied.
- Mothers were categorized based on smoking habits during pregnancy (non-smoking vs. smoking).
- Data collected included obstetric, demographic, and tobacco consumption information.
Main Results:
- Infants born to smoking mothers were significantly smaller, shorter, and had smaller body circumferences compared to non-smokers (p<0.001).
- Newborns of smoking mothers exhibited lower skinfold thicknesses, indicating reduced subcutaneous fat.
- While overall birth weight was affected, the Ponderal Index and subcutaneous fat distribution showed no significant differences between groups.
Conclusions:
- Maternal smoking leads to generalized fetal growth impairment, affecting most anthropometric parameters.
- Neonatal lean body mass appears to be disproportionately affected compared to body fat in infants of smoking mothers.
- Smoking during gestation is a primary determinant of birth weight, second only to gestational age.
Related Concept Videos
Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
