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Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
Published on: August 23, 2019
Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal
Marco Candela1, Silvia Turroni, Manuela Centanni
1Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro n.6, Bologna, Italy. marco.candela@unibo.it
Abstract:
Human plasmin(ogen) is regarded as a component of the molecular cross talk between the probiotic species Bifidobacterium animalis subsp. lactis and the human host. However, up to now, only in vitro studies have been reported. Here, we demonstrate that the probiotic strain B. animalis subsp. lactis BI07 is capable of recruiting plasmin(ogen) present at physiological concentrations in crude extracts from human feces. Our results provide evidence that supports the significance of the B. lactis-plasmin(ogen) interaction in the human gastrointestinal tract.
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