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Published on: March 6, 2019
Melanin biosynthesis inhibitors from Tarragon Artemisia dracunculus
Masayoshi Yamada1, Kazuhiko Nakamura, Taeko Watabe
1FANCL Research Institute, FANCL Corporation, Yokohama, Japan.
Abstract:
The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC(50) values for melanin biosynthesis inhibition were 1.8 and 2.3 µg/mL for 1 and 2.
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