Related Experiment Video
Updated: May 30, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
Published on: February 12, 2021
An encapsulated fruit and vegetable juice concentrate increases skin microcirculation in healthy women
S De Spirt1, H Sies, H Tronnier
1Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Düsseldorf, Germany.
Background/Aim:
Microcirculation in the dermis of the skin is important for nutrient delivery to this tissue. In this study, the effects of a micronutrient concentrate (Juice Plus+®; 'active group'), composed primarily of fruit and vegetable juice powder, on skin microcirculation and structure were compared to placebo.
Study Design/Methods:
This 12-week study had a monocentric, double-blind placebo and randomized controlled design with two treatment groups consisting of 26 healthy middle-aged women each. The 'oxygen to see' device was used to evaluate microcirculation. Skin density and thickness were measured using ultrasound. Measurements for skin hydration (Corneometer®), transepidermal water loss and serum analysis for carotenoids and α-tocopherol were also performed.
Results:
By 12 weeks, microcirculation of the superficial plexus increased by 39%. Furthermore, skin hydration increased by 9% while skin thickness increased by 6% and skin density by 16% in the active group. In the placebo group, microcirculation decreased, and a slight increase in skin density was observed.
Conclusion:
Ingestion of a fruit- and vegetable-based concentrate increases microcirculation of the skin at 12 weeks of intervention and positively affects skin hydration, density and thickness.
Related Concept Videos
Renewal of Skin Epidermal Stem Cells
Clinical Applications of Epidermal Stem Cells
Tissue Renewal without Stem Cells
However, failure of such a system...
The Skin Microbiota
Mineral, Vitamin and Water Absorption
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
