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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: May 30, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Comorbidities between nose and skin allergy.

Heidi Olze1, Torsten Zuberbier

  • 1Department of Otorhinolaryngology, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany. heidi.olze@charite.de

Current Opinion in Allergy and Clinical Immunology
|August 9, 2011
PubMed
Summary

Skin and nose allergies frequently coexist, sharing similar underlying mechanisms and genetic factors. These conditions, including atopic dermatitis and allergic rhinitis, are interconnected, not separate diseases.

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Area of Science:

  • Immunology
  • Dermatology
  • Otorhinolaryngology

Background:

  • Allergic skin conditions like atopic dermatitis and urticaria often present with nasal allergies.
  • Allergic rhinitis and chronic rhinosinusitis (CRS) are common nasal disorders.
  • Understanding comorbidities between skin and nasal allergies is crucial for comprehensive patient care.

Purpose of the Study:

  • To review comorbidities between nasal and skin allergies, focusing on allergic rhinitis, CRS, atopic dermatitis, and urticaria.
  • To compare the prevalence, pathophysiological mechanisms, genetic data, and therapeutic options for these related conditions.
  • To elucidate the interconnections between allergic skin and nasal disorders.

Main Methods:

  • Literature review of studies investigating comorbidities between nasal and skin allergies.
  • Comparative analysis of prevalence, pathophysiology, genetics, and treatment of selected allergic conditions.
  • Evaluation of shared etiological factors and therapeutic strategies.

Main Results:

  • Atopic dermatitis and allergic rhinitis show the strongest documented inter-relationships.
  • Comparable pathomechanisms, high prevalence, and coincidence observed across various comorbidities.
  • Key shared factors include IgE, mast cells, eosinophils, genetics, epithelial barrier defects, and Staphylococcus aureus colonization.

Conclusions:

  • Allergic skin disorders frequently exhibit comorbidities with nasal allergies like allergic rhinitis and CRS.
  • Distinct manifestations of these diseases affect both the nose and skin.
  • These conditions are interconnected through complex, not fully understood, relationships, indicating they are not separate entities.