Related Experiment Videos
Hydrochlorothiazide-induced acute pulmonary edema.
M S Kavaru1, M Ahmad, K N Amirthalingam
1Department of Pulmonary Disease, Cleveland Clinic Foundation, Ohio 44195.
Cleveland Clinic Journal of Medicine
|March 1, 1990
Summary
Hydrochlorothiazide can rarely cause acute pulmonary edema, a serious side effect. This review highlights supportive treatment for this condition, analyzing 17 cases.
Area of Science:
- Medicine
- Pharmacology
- Pulmonology
Background:
- Hydrochlorothiazide is a commonly prescribed diuretic.
- Acute pulmonary edema is a rare but severe adverse effect of hydrochlorothiazide.
- This condition has not been extensively documented in medical literature.
Purpose of the Study:
- To report a case of hydrochlorothiazide-induced acute pulmonary edema.
- To review existing literature on this adverse event.
- To emphasize the importance of recognizing and managing this condition.
Main Methods:
- Case report presentation.
- Systematic literature review of previously reported cases.
- Analysis of clinical presentation, treatment, and outcomes.
Main Results:
- Seventeen cases of hydrochlorothiazide-induced acute pulmonary edema were identified (1 case presented, 16 reviewed).
- The syndrome is characterized by rapid onset of respiratory distress following hydrochlorothiazide administration.
- Supportive care is the primary treatment modality.
Conclusions:
- Hydrochlorothiazide-induced acute pulmonary edema is a rare but critical adverse drug reaction.
- Prompt recognition and supportive management are essential for patient recovery.
- Further research may elucidate the underlying mechanisms and optimize treatment strategies.