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Updated: May 30, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Pleuroparenchymal fibroelastosis in patients with pulmonary disease secondary to bone marrow transplantation
Jan H von der Thüsen1, David M Hansell, Masaki Tominaga
1Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK. j.vonderthuesen@rbht.nhs.uk
Abstract:
This study presents four patients who underwent bone marrow transplantation and subsequently developed pleuroparenchymal fibroelastosis, hitherto reported as an idiopathic condition. All presented clinically with pneumothorax and subpleural fibrosis on high-resolution computed tomography. In addition to the expected obliterative bronchiolitis, histopathology showed coexistent subpleural changes, and the relationship of pathology in multiple anatomic compartments in post bone marrow transplantation pulmonary disease is discussed.
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