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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Yaoting Gui1, Guangwu Guo, Yi Huang

  • 1Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.

Nature Genetics
|August 9, 2011
PubMed

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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