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Updated: May 30, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

Published on: July 15, 2016

Mesenchymal stem cells: angels or demons?

Rebecca S Y Wong¹

¹Division of Human Biology, School of Medical and Health Sciences, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia. rebecca_wong@imu.edu.my

Journal of Biomedicine & Biotechnology

|August 9, 2011

Summary

This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise in treating diseases but can also promote tumor growth and drug resistance. Further research is needed to understand MSCs

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Published on: July 15, 2016

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

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Published on: October 8, 2016

Area of Science:

Cell Biology
Oncology
Regenerative Medicine

Background:

Mesenchymal stem cells (MSCs) are utilized in cell-based therapies for various conditions with encouraging outcomes.
Growing use of MSC therapy highlights concerns regarding adverse effects, particularly tumor modulation and malignant transformation.

Purpose of the Study:

To explore the dual role of MSCs in cancer, investigating their potential for tumor promotion and therapeutic targeting.
To address the urgent need for understanding MSC mechanisms in tumorigenesis and their clinical implications in cancer patients.

Main Methods:

Review of existing literature on MSC therapy and its effects on tumors.
Analysis of reported instances of MSC-mediated tumor enhancement, metastasis, and drug resistance.
Examination of studies documenting spontaneous malignant transformation of MSCs.

Main Results:

MSCs have demonstrated the capacity to enhance tumor growth and metastasis in certain contexts.
MSC therapy has been linked to increased resistance to anticancer drugs.
Spontaneous malignant transformation of MSCs has been observed in various studies.

Conclusions:

The mechanisms underlying MSC's tumor modulatory behavior and tumorigenic potential require urgent investigation.
Clinical application of MSCs in cancer patients necessitates further evaluation due to potential adverse effects.
If MSCs influence tumor progression, they could also represent potential targets for novel cancer treatments.