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Updated: May 30, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
High serum adiponectin concentration in children with chronic kidney disease
Kristina F Möller1, Christina Dieterman, Lena Herich
1Pediatric Nephrology, Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Hamburg Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. zepf@uke.uni-hamburg.de
Insights
Children with chronic kidney disease (CKD) exhibit elevated adiponectin (ADPN) levels, even post-transplant. This suggests ADPN
Area of Science:
- Pediatric Nephrology
- Endocrinology
- Cardiovascular Research
Background:
- Adiponectin (ADPN) is crucial in mitigating endothelial inflammation, a key factor in atherosclerosis development.
- Atherosclerosis is a significant concern in pediatric chronic kidney disease (CKD).
- Limited data exist regarding ADPN levels in children with CKD.
Purpose of the Study:
- To investigate serum ADPN concentrations in children with various renal disorders.
- To explore the relationship between ADPN levels and clinical parameters in pediatric CKD patients.
Main Methods:
- Serum ADPN levels were measured in 90 children with CKD (conservative, dialysis, post-transplant) and 27 healthy controls.
- Parameters including BMI, eGFR, lipids, homocysteine, hsCRP, and SBP were assessed.
- Multiple linear regression analysis was used to identify independent predictors of ADPN levels.
Main Results:
- Mean serum ADPN was significantly higher in all CKD patient groups (CKD, dialysis, post-transplant) compared to controls (p < 0.0001).
- Serum ADPN showed an inverse correlation with Body Mass Index (BMI) and Systolic Blood Pressure (SBP).
- SBP was the only independent factor associated with ADPN plasma levels in regression analysis.
Conclusions:
- Children with CKD, including those post-transplantation, demonstrate significantly elevated serum ADPN levels.
- The anti-atherosclerotic effects of ADPN in pediatric CKD may be linked to lower SBP.
- Further research is warranted to elucidate the role of ADPN and SBP in pediatric CKD progression.
Abstract:
Adiponectin (ADPN) counteracts the inflammatory response of the endothelium, which plays an important role in the development of atherosclerosis in patients with chronic kidney disease (CKD). Data in children with CKD are scarce. We examined serum ADPN concentration in 90 children with various renal disorders: 28 with CKD on conservative treatment (CKD), 21 on regular dialysis treatment (D), and 41 after kidney transplantation (Tx); 27 age-matched healthy children served as controls (C). Body mass index (BMI), estimated glomerular filtration rate (eGFR), lipids, homocysteine, high sensitivity CRP (hsCRP), and systolic blood pressure (SBP) were also measured. Mean serum ADPN concentration was significantly higher in patients with CKD (27.3 μg/ml ±15.0), on D (34.2 μg/ml ±14.9), and after Tx (23.6 μg/ml ±9.5) compared with ADPN levels in C (13.5 μg/ml ±6.1) (p < 0.0001). Serum ADPN concentration was inversely related to BMI (p = 0.001) and SBP (p = 0.004). In the multiple linear regression analysis, only SBP remained independently associated with ADPN plasma levels. Data show that children with CKD have significantly higher serum ADPN, even after Tx. The protective antiarthrosclerotic effect of ADPN may be mediated by lower SBP, a finding that deserves further study.
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