Related Experiment Video
Updated: May 30, 2026
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
In vivo biocompatibility of three potential intraperitoneal implants
Sylvie Defrère1, Mélanie Mestagdt, Raphaël Riva
1Université Catholique de Louvain, Institut de Recherche Clinique et Expérimentale, Department of Gynecology, Avenue Hippocrate 10, 1200 Brussels, Belgium.
Abstract:
The intraperitoneal biocompatibility of PDMS, polyHEMA and pEVA was investigated in rats, rabbits and rhesus monkeys. No inflammation was evidenced by hematological analyses and measurement of inflammatory markers throughout the experiment and by post-mortem examination of the pelvic cavity. After 3 or 6 months, histological analysis revealed fibrous tissue encapsulating PDMS and PEVA implants in all species and polyHEMA implants in rabbits and monkeys. Calcium deposits were observed inside polyHEMA implants. The intraperitoneal biocompatibility of all 3 polymers makes them suitable for the design of drug delivery systems, which may be of great interest for pathologies confined to the pelvic cavity.
