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Updated: May 30, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

[Androgen receptor mutation and progression of prostate cancer]

Jian-Guo Ma1, Wen-Ping Li, Yu-Qing Jiang

  • 1Department of Urology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|August 10, 2011
PubMed

Insights

Prostate cancer relies on androgen receptor signaling, but therapies fail as mutations cause resistance. This review covers mechanisms of tumor growth post-androgen receptor mutation and new treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Prostate cancer progression is driven by androgen receptor (AR) signaling.
  • Current therapies targeting AR signaling are effective but often lead to treatment resistance.
  • AR mutations are a key mechanism enabling cancer growth in advanced stages.

Purpose:

  • To review the molecular mechanisms driving tumor growth following androgen receptor mutation.
  • To discuss emerging management principles and chemotherapy options for advanced prostate cancer.

Summary:

  • Prostate cancer growth is critically dependent on the androgen receptor (AR) pathway.
  • Therapies blocking AR signaling are standard but invariably fail, leading to castration-resistant prostate cancer (CRPC).
  • AR mutations are frequently observed in CRPC, promoting continuous tumor growth through altered receptor activity.

Impact:

  • Understanding AR mutation mechanisms is crucial for developing effective treatments for advanced prostate cancer.
  • This review highlights promising therapeutic strategies and systemic chemotherapy options for managing AR-mutated prostate cancer.
  • Advances in understanding AR signaling and mutation provide new avenues for CRPC treatment.

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

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