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Updated: May 30, 2026

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution
Published on: June 23, 2022
New insights into the phylogenetic distribution and evolutionary origins of the septins
Ryuichi Nishihama1, Masayuki Onishi, John R Pringle
1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Abstract:
Until recently, it had appeared that the septin family of proteins was restricted to the opisthokont eukaryotes (the fungi and animals and their close relatives the microsporidia and choanoflagellates). It has now become apparent that septins are also present in several other widely divergent eukaryotic lineages (chlorophyte algae, brown algae, and ciliates). This distribution and the details of the non-opisthokont septin sequences appear to require major revisions to hypotheses about the origins and early evolution of the septins.
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