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Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
Published on: July 3, 2020
Lethal phenotype of mice carrying a Sept11 null mutation
Sabrina Röseler1, Kirstin Sandrock, Ingrid Bartsch
1Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany.
Biological Chemistry
|August 10, 2011
Summary
Septins are cytoskeletal proteins. The SEPT11 protein is crucial for embryonic development, as Sept11 null mutation in mice leads to in utero lethality and developmental defects.
Area of Science:
- Cell Biology
- Developmental Biology
Background:
- Septins are GTP-binding proteins essential for membrane dynamics.
- SEPT11 is ubiquitously expressed but highly abundant in the central nervous system and platelets.
- SEPT11 is implicated in vesicle trafficking and synaptic connectivity.
Purpose of the Study:
- To investigate the role of SEPT11 in embryonic development.
- To understand the function of SEPT11 in vivo.
Main Methods:
- Analysis of Sept11 null mutant mice.
- In utero embryonic development assessment.
Main Results:
- Homozygous Sept11 null mutation results in embryonic lethality.
- Developmental retardation observed from day 11.5 post coitum.
- Embryos were found dead from day 13.5 onwards.
Conclusions:
- SEPT11 is essential for embryonic development.
- Sept11 deficiency leads to severe developmental defects and in utero lethality.
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