Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optical bleaching front in bedrock revealed by spatially-resolved infrared photoluminescence.

Scientific reports·2019
Same author

Tetrahydroquinolinone derivatives as potent P-glycoprotein inhibitors: design, synthesis, biological evaluation and molecular docking analysis.

MedChemComm·2018
Same author

RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2017
Same author

RIFM fragrance ingredient safety assessment, dihydro-α-terpineol, CAS Registry Number 498-81-7.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2017
Same author

Re: Re: Le Fort I advancement osteotomies of 1cm or more. How safe or stable?

The British journal of oral & maxillofacial surgery·2017
Same author

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, Methyl jasmonate, CAS Registry Number 1211-29-6.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2017

Related Experiment Video

Updated: May 30, 2026

Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology
07:05

Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology

Published on: August 23, 2024

Coumarins as antioxidants.

I Kostova1, S Bhatia, P Grigorov

  • 1Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia 1000, Bulgaria. irenakostova@yahoo.com

Current Medicinal Chemistry
|August 10, 2011
PubMed
Summary
This summary is machine-generated.

This review highlights coumarins, natural compounds with significant antioxidant properties. Understanding their mechanisms aids in designing novel antioxidants for cellular protection.

More Related Videos

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

Related Experiment Videos

Last Updated: May 30, 2026

Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology
07:05

Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology

Published on: August 23, 2024

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Biochemistry

Background:

  • Coumarins are a class of naturally occurring compounds with diverse biochemical and pharmacological effects.
  • Recent research focuses on coumarins as potential antioxidant agents.
  • This review updates existing literature on coumarins' antioxidant capabilities.

Purpose of the Study:

  • To provide a comprehensive overview of coumarins' antioxidant properties.
  • To highlight novel mechanisms of action for coumarin-based antioxidants.
  • To serve as a basis for the rational design of new antioxidant compounds.

Main Methods:

  • Literature review of recently published studies on coumarins and their antioxidant activity.
  • Analysis of natural sources, particularly green plants, for coumarin identification.
  • Examination of synthetic and natural coumarins' mechanisms of action.

Main Results:

  • Numerous coumarins have been identified from natural sources, acting as leads for drug design.
  • Coumarins offer a promising avenue for discovering antioxidants with unique mechanisms.
  • Existing knowledge of coumarin mechanisms is crucial for developing new analogues.

Conclusions:

  • Coumarins are valuable natural compounds with significant antioxidant potential.
  • Further research into coumarin mechanisms will facilitate the development of novel therapeutic agents.
  • The rational design of antioxidants can be advanced through a deep understanding of coumarins.