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Related Experiment Video

Updated: May 30, 2026

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

Antioxidant therapy: current status and future prospects.

O Firuzi¹, R Miri, M Tavakkoli

¹Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. firuzio@sums.ac.ir

Current Medicinal Chemistry

|August 10, 2011

Summary

This summary is machine-generated.

Antioxidants combat harmful reactive oxygen species (ROS), but clinical trial success varies. Focusing on targeted, bioavailable antioxidants may improve therapeutic outcomes for oxidative stress diseases.

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Published on: February 7, 2018

Area of Science:

Biochemistry
Pharmacology
Clinical Medicine

Background:

Reactive oxygen species (ROS) are implicated in numerous human diseases.
Antioxidants are hypothesized to mitigate ROS-induced damage and prevent/treat oxidative stress-related conditions.

Purpose of the Study:

To review recent human studies on antioxidant efficacy in disease prevention and treatment.
To explore reasons for the variable success of antioxidant therapies in clinical trials.

Main Methods:

Review of recent human clinical studies on antioxidant efficacy.
Analysis of factors contributing to the success or failure of antioxidant interventions.

Main Results:

Several antioxidants (edaravone, N-acetylcysteine, alpha-lipoic acid, specific flavonoids) have achieved clinical acceptance for certain conditions.
Many widely studied antioxidants, including vitamins and nitrones, have failed to demonstrate efficacy in large clinical trials.
Compelling epidemiological and preclinical data support the benefits of dietary antioxidants.

Conclusions:

The clinical success of antioxidants is condition- and agent-specific.
Future antioxidant therapy may benefit from a focus on disease-specific, highly bioavailable compounds rather than broad-spectrum agents like antioxidant vitamins.
Further research is needed to optimize antioxidant therapeutic strategies.