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Coeliac disease in children: a social epidemiological study in Sweden

Carl Johan Wingren1, Sara Björck, Kristian F Lynch

  • 1Unit for Social Epidemiology, Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden. carl_johan.wingren@med.lu.se

Acta Paediatrica (Oslo, Norway : 1992)
|August 10, 2011
PubMed

Insights

Low socioeconomic position (SEP) is linked to early coeliac disease (CD) risk in boys, but not girls. Geographical variations in CD risk were also observed in children under two.

Area of Science:

  • Pediatric Epidemiology
  • Gastroenterology
  • Public Health

Background:

  • Socioeconomic and geographical disparities in early coeliac disease (CD) risk are not well understood.
  • Investigating early-life risk factors for CD is crucial for understanding disease etiology.

Purpose of the Study:

  • To examine socioeconomic position (SEP) and geographical variations in the risk of developing coeliac disease (CD) in children under two years of age.
  • To determine if individual characteristics explain geographical differences in CD risk.

Main Methods:

  • Utilized Swedish national registries to identify 792,401 singletons born between 1987 and 1993.
  • Followed children until age two to diagnose coeliac disease (CD).
  • Applied multilevel logistic regression to analyze associations between SEP, geography, and CD risk.

Main Results:

  • Low socioeconomic position (SEP) was associated with an increased risk of coeliac disease (CD) in boys (OR 1.37).
  • No significant association between low SEP and CD risk was found in girls (OR 0.87).
  • A significant geographical variation in CD risk was observed (intra-municipality correlation ≈ 10%), unexplained by individual factors.

Conclusions:

  • Low SEP is a potential risk factor for early coeliac disease (CD) in boys, but not girls.
  • Geographical location of residence appears to influence CD risk.
  • Further research is needed to elucidate the underlying reasons for observed geographical and socioeconomic disparities in pediatric CD.
Abstract

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