Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing anastomosis safety with intraoperative perfusion assessment: a visual grading system for tailoring resection and ostomy formation in sigmoid colon and rectal cancer surgery.

Annals of coloproctology·2026
Same author

ASO Visual Abstract: Predominance of Peritoneal Metastasis in the Recurrence Pattern of T4 Colorectal Cancer: A Retrospective Cohort Study.

Annals of surgical oncology·2026
Same author

Predominance of Peritoneal Metastasis in the Recurrence Pattern of T4 Colorectal Cancer: A Retrospective Cohort Study.

Annals of surgical oncology·2026
Same author

Risk factors for residual cancer and lymph node metastasis after non-curative endoscopic resection of colorectal cancer: a multicenter retrospective study.

BMC gastroenterology·2026
Same author

Impact of sarcopenia on postoperative outcomes and recurrence in patients with Crohn disease: A retrospective cohort study.

Medicine·2026
Same author

Intratumoral PKM2 expression predicts benefit from adjuvant FOLFOX in stage II-III colorectal cancer.

Journal of gastrointestinal oncology·2026

Related Experiment Video

Updated: May 30, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Steroid-refractory cryptogenic multifocal ulcerous stenosing enteritis.

Chan Wook Kim1, Chang Sik Yu, Yong Sik Yoon

  • 1Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, 388-1 Poongnap-2-Dong, Songpa-Ku, Seoul 138-736, Korea.

American Journal of Surgery
|August 10, 2011
PubMed
Summary

Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare condition. This case highlights the need for new treatments for steroid-refractory CMUSE to prevent complications like short-bowel syndrome.

More Related Videos

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Related Experiment Videos

Last Updated: May 30, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Area of Science:

  • Gastroenterology
  • Rare Diseases
  • Inflammatory Bowel Disease

Background:

  • Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare gastrointestinal disorder with unknown etiology and pathophysiology.
  • Current management focuses on symptomatic relief, with corticosteroids being the primary medical intervention.

Observation:

  • A 25-year-old female patient presented with recurrent small-bowel obstructions, necessitating four surgical interventions.
  • The patient was diagnosed with CMUSE and demonstrated steroid-refractory disease despite undergoing immunosuppressive therapy.

Findings:

  • Despite conventional treatments, the patient experienced persistent gastrointestinal symptoms and anemia.
  • The steroid-refractory nature of CMUSE poses significant challenges in managing the condition.

Implications:

  • This case underscores the critical need for novel therapeutic strategies for steroid-refractory CMUSE.
  • Developing new treatments is essential to prevent severe complications such as short-bowel syndrome and improve patient outcomes.