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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

C-kit expression in canine mucosal melanomas.

S J Newman¹, J M Jankovsky, B W Rohrbach

¹Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996-4542, USA. snewman4@utk.edu

Veterinary Pathology

|August 10, 2011

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Canine melanomas show altered c-kit receptor (KIT) expression. KIT expression in tumors correlated with longer survival, suggesting its potential as a prognostic indicator for mucosal melanomas in dogs.

Area of Science:

Veterinary Pathology
Oncology
Molecular Biology

Background:

The c-kit receptor (KIT) is crucial for melanocyte migration signals; its reduced expression is linked to human melanoma progression.
KIT expression has not been previously studied in canine melanocytic neoplasms.

Purpose of the Study:

To investigate c-kit (KIT) expression in benign and malignant canine melanocytic tumors.
To evaluate the potential of KIT expression as a prognostic marker for canine mucosal melanomas.

Main Methods:

Immunohistochemical analysis of KIT expression in 14 benign dermal melanocytomas and 61 malignant mucosal melanomas.
Melan A expression was used to confirm melanocytic origin of tumors.

Main Results:

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All benign dermal melanocytomas showed strong and diffuse KIT expression.
KIT was detected in various melanocyte populations within mucosal melanomas (basilar, junctional, neoplastic).
KIT expression within resected melanomas was significantly associated with longer patient survival.

Conclusions:

Canine mucosal melanomas exhibit altered KIT expression compared to normal melanocytes.
KIT expression may serve as a valuable prognostic indicator for canine mucosal melanomas.