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Radiotherapy for high grade gliomas.

G E Sheline1

  • 1Dept. of Radiation Oncology, University of California, San Francisco 94143.

International Journal of Radiation Oncology, Biology, Physics
|April 1, 1990
PubMed
Summary

This review examines radiotherapy for high-grade gliomas, incorporating data from major clinical trials. It highlights treatment outcomes and the role of chemotherapy in conjunction with radiation therapy.

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Area of Science:

  • Neuro-oncology
  • Radiation Oncology

Background:

  • High-grade gliomas are aggressive brain tumors requiring multimodal treatment strategies.
  • Radiotherapy is a cornerstone in managing these challenging malignancies.

Purpose of the Study:

  • To review current data on the efficacy of radiotherapy in treating high-grade gliomas.
  • To analyze results from prospective randomized clinical trials investigating radiotherapy and chemotherapy combinations.

Main Methods:

  • Review of recent data from cooperative clinical trials.
  • Focus on prospective randomized trials conducted internationally.
  • Inclusion of studies combining radiotherapy with chemotherapy.

Main Results:

  • Presentation of recent findings on high-grade glioma treatment outcomes.
  • Emphasis on radiotherapy's role, including combination therapies.
  • Analysis of data from large-scale, multi-institutional trials.

Conclusions:

  • Radiotherapy remains a critical component in high-grade glioma management.
  • Combined modality treatments involving chemotherapy show evolving results.
  • International collaborative trials provide robust evidence for treatment advancements.

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