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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Kidney aging--inevitable or preventable?

Devasmita Choudhury1, Moshe Levi

  • 1Dallas VA Medical Center, The University of Texas Southwestern Medical Center, Dallas, TX 75216, USA.

Nature Reviews. Nephrology
|August 10, 2011
PubMed
Summary
This summary is machine-generated.

Kidney aging involves progressive scarring and function decline. Lifestyle and clinical factors like hypertension and diabetes accelerate this process, but interventions may help prevent it.

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Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

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Last Updated: May 30, 2026

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Published on: April 4, 2025

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
08:53

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Area of Science:

  • Nephrology
  • Gerontology
  • Internal Medicine

Background:

  • The aging process impacts all organs, including the kidneys.
  • Progressive renal scarring and functional decline are common with age.
  • Understanding renal aging is crucial for geriatric health.

Purpose of the Study:

  • To review the clinical and tissue factors associated with age-related kidney decline.
  • To explore potential interventions for mitigating renal aging.
  • To assess the preventability of kidney aging.

Main Methods:

  • Literature review of aging processes and kidney function.
  • Analysis of clinical factors linked to renal sclerosis.
  • Examination of tissue-specific factors in renal aging.

Main Results:

  • Clinical factors (hypertension, diabetes, obesity, dyslipidemia, vitamin D deficiency) correlate with age-related renal sclerosis.
  • Tissue factors (angiotensin II, advanced glycation end products, oxidative stress, Klotho) are implicated in renal aging.
  • Interventions targeting blood pressure, blood sugar, weight, and diet show promise.

Conclusions:

  • Renal aging is influenced by a combination of clinical and tissue-specific factors.
  • Lifestyle modifications and medical management can potentially slow or prevent kidney aging.
  • Renal aging may be more preventable than previously thought.