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Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
Published on: March 1, 2016
Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials
Matthias T Stephan1, Darrell J Irvine
1Department of Material Science and Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.
Nano Today
|August 10, 2011
Summary
Living cell therapies are advancing for various diseases. Surface engineering with nanomaterials offers new ways to improve therapeutic cell function, complementing genetic methods.
Area of Science:
- Biomedical Engineering
- Materials Science
- Cell Therapy
Background:
- Living cell injection therapies are used for cancer, cardiovascular disease, and diabetes.
- Enhancing therapeutic cell efficacy is crucial for improving patient outcomes.
Purpose of the Study:
- To explore chemical and materials science strategies for engineering therapeutic cells.
- To synthetically endow donor cells with enhanced properties and functions.
Main Methods:
- Surface modification of therapeutic cells using molecules, artificial receptors, and nanomaterials.
- Investigating synthetic approaches to imbue cells with new functionalities.
Main Results:
- Demonstrated feasibility of surface engineering for therapeutic cells.
- Showcased the potential of nanomaterials in enhancing cell function.
Conclusions:
- Surface engineering presents a powerful alternative/complement to genetic modification for therapeutic cells.
- These advanced strategies hold promise for improving cell-based disease treatments.
