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Related Experiment Video

Updated: May 30, 2026

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

[Circulating tumor cells: detection, characterization and clinical impact].

C Gilles1, J Collignon, A Noël

  • 1Laboratoire de Biologie des Tumeurs et du Développement, GIGA-Cancer, Université de Liège, CHU de Liège, Belgique. cgilles@ulg.ac.be

Revue Medicale De Liege
|August 11, 2011
PubMed
Summary

Detecting circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) is crucial for understanding cancer metastasis and recurrence. Ongoing research aims to overcome technical challenges in isolating these cells for improved patient outcomes.

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Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
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Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
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Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Related Experiment Videos

Last Updated: May 30, 2026

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
07:47

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Context:

  • Metastasis involves circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) forming occult metastases.
  • Current isolation and identification methods for CTCs and DTCs face significant technical limitations.

Purpose:

  • To highlight the growing importance of CTC research in oncology.
  • To underscore the clinical potential of CTCs in predicting metastasis, recurrence, and patient survival.
  • To emphasize the role of CTCs and DTCs in understanding cancer relapse due to stem cell properties.

Summary:

  • Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are key components of the metastatic process.
  • Despite technical challenges, CTC research is expanding due to their clinical significance.
  • CTCs offer predictive insights into metastasis and recurrence, and prognostic information on survival.
  • Enumeration of CTCs may enable monitoring of treatment efficacy.
  • Subpopulations of stem-like cells within CTCs and DTCs are implicated in cancer relapse.

Impact:

  • Advances in CTC detection can lead to personalized cancer treatment strategies.
  • Improved understanding of CTCs and DTCs will enhance prognostic accuracy and patient monitoring.
  • This research contributes to developing more effective therapies targeting metastasis and preventing relapse.